METHOD FOR PRODUCING DEAD LACTIC ACID BACTERIA CELLS HAVING ENHANCED IMMUNOREGULATORY FUNCTION

• Main Authors: PARK, Jae Seung, YUN, Hyun Sun, LEE, Jayoung, JUNG, Hee Kyoung, JUNG, Woo-yong, KIM, Min-su
• Format: Patent
• Language: English; French; Korean
• Published: 08.02.2024
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FODDER; FOODS OR FOODSTUFFS; FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL; PROCESSES USING MICROORGANISMS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES; VINEGAR; WINE

The present application relates to: a method for producing dead lactic acid bacteria cells, comprising a step of performing primary heat treatment and secondary heat treatment on any one or more lactic acid bacteria selected from the group consisting of the strains of Lactobacillus plantarum CJLP133 deposited with accession number KCTC 11403BP, Lactobacillus plantarum CJLP243 deposited with accession number KCCM 11045P, and Lactobacillus plantarum CJLP55 deposited with accession number KCTC 11401BP; a method for increasing the immunoregulatory function of dead lactic acid bacteria cells; a method for increasing an interferon gamma production ability or an interleukin-4 reduction ability of dead lactic acid bacteria cells; a method for increasing the ability to inhibit the attachment of harmful intestinal bacteria; dead lactic acid bacteria cells produced thereby; and an immunoregulatory food, pharmaceutical and feed composition, which include the dead lactic acid bacteria cells. La présente invention concerne : un procédé de production de cellules de bactéries lactiques mortes, comprenant une étape de réalisation d'un traitement thermique primaire et d'un traitement thermique secondaire sur une ou plusieurs bactéries lactiques choisies dans le groupe constitué par les souches de Lactobacillus plantarum CJLP133 déposées avec le numéro d'accès KCTC 11403 BP, Lactobacillus plantarum CJLP243 déposé avec le numéro d'accès KCCM 11045P, et Lactobacillus plantarum CJLP55 déposé avec le numéro d'accès KCTC 11401 BP ; un procédé pour augmenter la fonction immunorégulatrice de cellules de bactéries lactiques mortes ; un procédé pour augmenter une capacité de production de gamma d'interféron ou une capacité de réduction d'interleukine -4 de cellules de bactéries lactiques mortes ; un procédé pour augmenter la capacité à inhiber la fixation de bactéries intestinales nocives ; des cellules de bactéries lactiques mortes produites par celui-ci ; et une composition alimentaire immunorégulatrice, pharmaceutique et d'alimentation, qui comprennent les cellules de bactéries lactiques mortes. 본 출원은 수탁번호 KCTC 11403BP로 기탁된 락토바실러스 플란타룸 CJLP133, 수탁번호 KCCM 11045P로 기탁된 락토바실러스 플란타룸 CJLP243, 및 수탁번호 KCTC 11401BP로 기탁된 락토바실러스 플란타룸 CJLP55 균주로 구성되는 군에서 선택되는 어느 하나 이상의 유산균을 제1열처리 및 제2열처리하는 단계를 포함하는, 유산균 사균체 제조 방법; 유산균 사균체의 면역 조절능을 증가시키는 방법; 유산균 사균체의 인터페론 감마 생성능 또는 인터루킨-4 감소능을 증가시키는 방법; 장내 유해균 부착 억제능을 증가시키는 방법; 상기 방법으로 제조된 유산균 사균체; 및 상기 유산균 사균체를 포함하는 면역 조절용 식품, 약학적, 및 사료 조성물에 관한 것이다.