BCL-XL DEGRADING COMPOUNDS

Provided herein are heteroaromatic compounds which target Bcl-xL proteins for ubiquitination and proteasomal degradation. Also provided herein are methods for using said compounds for the treatment of diseases. L'invention concerne des composés hétéroaromatiques qui ciblent des protéines Bcl-xL...

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Main Authors HE, Long, GUO, Bingshi, CAO, Min, XIE, Yang, CHEN, Hang, LEI, Ying, DIAO, Jianxiong, XING, Weiqiang, LAI, Weiting, LIU, Fan, CHEN, Mingchen
Format Patent
LanguageEnglish
French
Published 08.02.2024
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Provided herein are heteroaromatic compounds which target Bcl-xL proteins for ubiquitination and proteasomal degradation. Also provided herein are methods for using said compounds for the treatment of diseases. L'invention concerne des composés hétéroaromatiques qui ciblent des protéines Bcl-xL pour l'ubiquitination et la dégradation protéasomale. L'invention concerne également des méthodes d'utilisation desdits composés pour le traitement de maladies.
Bibliography:Application Number: WO2023CN110543