PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING OSTEOARTHRITIS

• Main Authors: CHO, Mi La, SOHN, Hee Su, JHUN, Joo Yeon, NA, Hyun Sik, CHOI, Jeong Won, KIM, Byung Soo
• Format: Patent
• Language: English; French; Korean
• Published: 01.02.2024
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention may provide a pharmaceutical composition for preventing or treating osteoarthritis, the composition comprising a carrier containing type 2 collagen peptide and rapamycin. Ideally, the composition may reduce inflammatory responses that occur in joints due to inflammatory immune cells, alleviate cartilage destruction and pain that accompany inflammatory responses and, further, may regenerate cartilage. Furthermore, the composition of the present invention contains antigens associated with other diseases in addition to osteoarthritis and thus may be utilized as a therapeutic agent for inflammatory diseases such as myocardial infarction, cerebral infarction, and spinal cord injuries, or autoimmune diseases such as atopy, rheumatoid arthritis, type 1 diabetes, Crohn's disease, and lupus. La présente invention peut fournir une composition pharmaceutique pour la prévention ou le traitement de l'arthrose, la composition comprenant un support contenant un peptide de collagène de type 2 et de la rapamycine. Idéalement, la composition peut réduire les réponses inflammatoires qui se produisent dans les articulations en raison de cellules immunitaires inflammatoires, atténuer la destruction du cartilage et la douleur qui accompagnent les réponses inflammatoires et, en outre, peut régénérer le cartilage. En outre, la composition de la présente invention contient des antigènes associés à d'autres maladies en plus de l'arthrose et peut ainsi être utilisée en tant qu'agent thérapeutique pour des maladies inflammatoires telles que l'infarctus du myocarde, l'infarctus cérébral et les lésions de la moelle épinière, ou des maladies auto-immunes telles que l'atopie, la polyarthrite rhumatoïde, le diabète de type 1, la maladie de Crohn et le lupus. 본 발명은 제 2형 콜라겐 펩타이드 및 라파마이신을 담지하는 전달체를 포함하는 골관절염의 예방 또는 치료용 약학 조성물을 제공할 수 있다. 이는 바람직하게는 관절에서 발생하는 염증성 면역세포에 의한 염증반응을 감소시키면서, 염증반응으로 수반되는 연골 파괴 및 통증을 완화시키고, 더 나아가서는 연골을 재생시킬 수 있다. 본 발명의 조성물은 더 나아가 골관절염뿐 아니라, 다른 질병 관련 항원을 담지하여 심근경색, 뇌경색, 척추손상 등의 염증성 질환 또는 아토피, 류마티스관절염, 1형 당뇨병, 크론병, 루푸스 등 자가면역질환의 치료제로서 활용할 수 있다.