HEXACYCLIC TOPOISOMERASE INHIBITORS HAVING CYTOTOXIC ACTIVITY ON CANCER CELLS

Disclosed are topoisomerase inhibitor compounds as cytotoxic agents and further as payloads for antibody-drug conjugates. Also disclosed are methods of making and use of the compounds in the treatment of proliferative diseases. L'invention concerne des composés inhibiteurs de topoisomérase en t...

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Bibliographic Details
Main Authors PANTH, Nabin, JAIN, Nareshkumar, PRIOR, Allan, MURKLI, Steven, BHUJADE, Arti
Format Patent
LanguageEnglish
French
Published 25.01.2024
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Disclosed are topoisomerase inhibitor compounds as cytotoxic agents and further as payloads for antibody-drug conjugates. Also disclosed are methods of making and use of the compounds in the treatment of proliferative diseases. L'invention concerne des composés inhibiteurs de topoisomérase en tant qu'agents cytotoxiques et également en tant que charges utiles pour des conjugués anticorps-médicament. L'invention concerne en outre des procédés de fabrication et d'utilisation desdits composés dans le traitement de maladies prolifératives.
Bibliography:Application Number: WO2023US70686