NOVEL HETEROCYCLIC COMPOUND AND PHARMACEUTICAL COMPOSITION FOR INHIBITING AUTOTAXIN COMPRISING THE SAME

• Main Authors: NOH, Hyeon Seok, HAN, Na Ra, KIM, Shin Ae, SHIN, Soo Jeong, LEE, Jae Un, LEE, Bong Yong, SHIN, Young Ah, CHO, Young Kyoung, LEE, Jae Sang
• Format: Patent
• Language: English; French; Korean
• Published: 25.01.2024
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention provides: a novel heterocyclic compound, a hydrate thereof, a solvate thereof, or a pharmaceutically acceptable salt thereof; and a pharmaceutical composition for preventing or treating a disease related to autotaxin activity, the composition comprising same as an active ingredient. The heterocyclic compound of the present invention exhibits excellent inhibitory activity against autotaxin, and thus can be used in the treatment and prevention of diseases related to autotaxin inhibition, such as fibrotic diseases, inflammatory diseases, autoimmune diseases, respiratory diseases, cardiovascular diseases, metabolic diseases, cancer and cancer metastasis, ocular diseases, chronic pruritus in a cholestatic form and other forms, and acute or chronic organ transplant rejection. La présente invention concerne : un nouveau composé hétérocyclique, un hydrate, un solvate ou un sel pharmaceutiquement acceptable de celui-ci ; et une composition pharmaceutique pour prévenir ou traiter une maladie liée à l'activité de l'autotaxine, la composition comprenant celui-ci en tant que principe actif. Le composé hétérocyclique selon la présente invention a une excellente activité inhibitrice contre l'autotaxine, et peut ainsi être utilisé dans le traitement et la prévention de maladies liées à l'inhibition de l'autotaxine, telles que les maladies fibrotiques, les maladies inflammatoires, les maladies auto-immunes, les maladies respiratoires, les maladies cardiovasculaires, les maladies métaboliques, le cancer et les métastases cancéreuses, les maladies oculaires, le prurit chronique dans une forme cholestatique et d'autres formes, et le rejet de greffe d'organe aigu ou chronique. 본 발명은 신규한 헤테로사이클릭 화합물, 이의 수화물, 이의 용매화물 또는 이의 약학적으로 허용가능한 염과, 이를 유효성분으로 포함하는 오토탁신 활성과 관련된 질환의 예방 또는 치료용 약학 조성물을 제공한다. 본 발명의 헤테로사이클릭 화합물은 오토탁신에 대하여 우수한 억제 활성을 나타내어, 오토탁신의 저해와 관련된 질환인 섬유화 질환, 염증성 질환, 자가면역 질환, 호흡기 질환, 심혈관 질환, 대사성 질환, 암 및 암전이, 안구 질환, 담즙울체성 형태 및 다른 형태의 만성소양증, 및 급성 또는 만성 장기이식 거부반응의 치료 및 예방에 유용하게 사용될 수 있다.