HETEROARYL DERIVATIVES AS DDRs INHIBITORS

The present invention relates to compounds of formula (I) inhibiting Discoidin Domain Receptors (DDR inhibitors), methods of preparing such compounds, intermediate compounds useful in such preparations, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the inv...

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Main Authors RIZZI, Andrea, HAMASOVA, Zuzana, WHITTAKER, Benjamin Paul, IOTTI, Nicolò, GHIDINI, Eleonora, MAZZUCATO, Roberta, CARZANIGA, Laura, CHAPMAN, Robert Stuart Laurie, CIANCIUSI, Annarita
Format Patent
LanguageEnglish
French
Published 25.01.2024
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present invention relates to compounds of formula (I) inhibiting Discoidin Domain Receptors (DDR inhibitors), methods of preparing such compounds, intermediate compounds useful in such preparations, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful for instance in the treatment of many disorders associated with DDR mechanisms. La présente invention concerne des composés de formule (I) inhibant les récepteurs du domaine discoïdine (inhibiteurs de DDR), des procédés de préparation de tels composés, des composés intermédiaires utiles dans de telles préparations, des compositions pharmaceutiques les contenant et leur utilisation thérapeutique. Les composés de l'invention peuvent être utiles, par exemple, dans le traitement de nombreux troubles associés aux mécanismes DDR.
Bibliography:Application Number: WO2023EP69886