SUBSTITUTED 3-(1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE/2-(2,6-DIOXOPIPERIDIN-3-YL)ISOINDOLINE-1,3-DIONE ANALOGS AS MODULATORS OF CEREBLON PROTEIN

• Main Authors: RANKOVIC, Zoran, NISHIGUCHI, Gisele A
• Format: Patent
• Language: English; French
• Published: 18.01.2024
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The present disclosure relates to substituted 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione/2-(6-dioxopiperidin-3-yl) isoindoline-1,3-dione analogs that useful as modulators of cereblon (CRBN) activity, methods of making same, pharmaceutical compositions comprising same, and methods of treating vario...