SUBSTITUTED 3-(1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE/2-(2,6-DIOXOPIPERIDIN-3-YL)ISOINDOLINE-1,3-DIONE ANALOGS AS MODULATORS OF CEREBLON PROTEIN

The present disclosure relates to substituted 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione/2-(6-dioxopiperidin-3-yl) isoindoline-1,3-dione analogs that useful as modulators of cereblon (CRBN) activity, methods of making same, pharmaceutical compositions comprising same, and methods of treating vario...

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Bibliographic Details
Main Authors RANKOVIC, Zoran, NISHIGUCHI, Gisele A
Format Patent
LanguageEnglish
French
Published 18.01.2024
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present disclosure relates to substituted 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione/2-(6-dioxopiperidin-3-yl) isoindoline-1,3-dione analogs that useful as modulators of cereblon (CRBN) activity, methods of making same, pharmaceutical compositions comprising same, and methods of treating various clinical conditions and disorders using same, e.g., a disorder of uncontrolled cellular proliferation, such as a cancer, which may be associated with cereblon protein dysfunction. La présente divulgation concerne des analogues de 3-(1-oxoisoindolin-2-yl) pipéridine -2,6-dione/2-(6-dioxopipéridin-3-yl)isoindoline-1,3-dione substitués qui sont utiles en tant que modulateurs de l'activité de céréblon (CRBN), des méthodes de production de ceux-ci, des compositions pharmaceutiques les comprenant, et des méthodes de traitement de diverses affections et troubles cliniques les utilisant, par exemple, un trouble de prolifération cellulaire incontrôlée, tel qu'un cancer, qui peut être associé à un dysfonctionnement de protéine céréblon.
Bibliography:Application Number: WO2023US27841