TYROSINE KINASE 2 INHIBITORS AND USES THEREOF

This disclosure relates to compounds of Formula (I) or pharmaceutically acceptable salts thereof, in which all of the variables in Formula (I) are as defined in the application. The compounds of this disclosure are capable of inhibiting the activity of tyrosine kinase 2 (TYK2). The disclosure furthe...

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Bibliographic Details
Main Authors LEVIN, Tamara, LIN, Edward, MAITRA, Soma, GUCKIAN, Kevin, HELAL, Christopher, PATTAROPONG, Vatee, VESSELS, Jeffrey, VANDEVEER, Harold, LOPEZ DE TURISO, Felix, SCIABOLA, Simone, XIN, Zhili
Format Patent
LanguageEnglish
French
Published 18.01.2024
Subjects
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:This disclosure relates to compounds of Formula (I) or pharmaceutically acceptable salts thereof, in which all of the variables in Formula (I) are as defined in the application. The compounds of this disclosure are capable of inhibiting the activity of tyrosine kinase 2 (TYK2). The disclosure further provides methods of preparing the compounds of the disclosure, and methods for their therapeutic use. La présente invention concerne des composés de formule (I) ou des sels pharmaceutiquement acceptables de ceux-ci, toutes les variables dans la formule (I) étant telles que définies dans l'application. Les composés de la présente invention sont capables d'inhiber l'activité de la tyrosine kinase 2 (TYK2). L'invention concerne en outre des procédés de préparation des composés de l'invention, et des procédés pour leur utilisation thérapeutique.
Bibliography:Application Number: WO2023US27603