PRMT5 INHIBITOR, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL USE THEREOF

A PRMT5 inhibitor, a preparation method therefor, and the pharmaceutical use thereof. In particular, the present invention relates to a PRMT5 inhibitor having a structure of formula (I), a preparation method therefor, a pharmaceutical composition containing same, and the use of same as a PRMT5 inhib...

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Main Authors YANG, Fei, CHEN, Zhui, LIU, Zhaomin, XU, Yaochang, LIU, Jian, YU, Hongping, DENG, Haibing
Format Patent
LanguageChinese
English
French
Published 18.01.2024
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:A PRMT5 inhibitor, a preparation method therefor, and the pharmaceutical use thereof. In particular, the present invention relates to a PRMT5 inhibitor having a structure of formula (I), a preparation method therefor, a pharmaceutical composition containing same, and the use of same as a PRMT5 inhibitor and the use of same for treatment and/or prevention of PRMT5-mediated diseases. Each substituent of formula (I) is as defined in the description. L'invention concerne un inhibiteur de PRMT5, son procédé de préparation et son utilisation pharmaceutique. En particulier, la présente invention concerne un inhibiteur de PRMT5 ayant une structure de formule (I), son procédé de préparation, une composition pharmaceutique le contenant, et son utilisation en tant qu'inhibiteur de PRMT5 et son utilisation pour le traitement et/ou la prévention de maladies médiées par PRMT5. Chaque substituant de formule (I) est tel que défini dans la description. 一种PRMT5抑制剂，其制备方法和在药学上的应用。特别地，涉及一种具有式(I)结构的PRMT5抑制剂及其制备方法、含有其的药物组合物，以及其作为PR
Bibliography:Application Number: WO2023CN105579