PYRAZOLO[3,4-D]PYRIMIDIN-6-YL-SULFONAMIDE DERIVATIVES FOR THE INHIBITION OF SGK-1 AND TREATMENT OF CANCER

• Main Authors: KHALIFA, Maroua, CAMPEAU, Eric, VIDAL, Marc, LABIT, Delphine, MAGUIRE, Martin
• Format: Patent
• Language: English; French
• Published: 18.01.2024
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; TESTING

Compounds of Formula I: Formula I and pharmaceutically acceptable salts thereof are provided for as inhibitors of SGK-1 for example for the treatment of conditions such as Long QT syndrome, heart failure, arrhythmia, ischemic injury, ischemic infarction, cardiac fibrosis, vascular proliferation, restenosis, dilated cardiomyopathy, stent failure, cancer, Parkinson's disease and Lafora disease. L'invention concerne des composés représentés par la formule I et ses sels pharmaceutiquement acceptables, utilisés comme inhibiteurs de la SGK-1, par exemple pour le traitement d'états pathologiques, tels que le syndrome du QT long, l'insuffisance cardiaque, l'arythmie, la lésion ischémique, l'infarctus ischémique, la fibrose cardiaque, la prolifération vasculaire, la resténose, la cardiomyopathie dilatée, la défaillance d'endoprothèse, le cancer, la maladie de Parkinson et la maladie de Lafora.