ANTIBODIES AND METHODS OF MAKING AND USING SAME

Antibodies having enhanced biodistribution and/or pharmacokinetics obtained through disruption of one or more clusters of surface-exposed positively charged amino acids are provided. Also provided are methods of enhancing the biodistribution and/or pharmacokinetics of an antibody. The enhanced antib...

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Bibliographic Details
Main Authors DE SOUZA, CORDEIRO, MASCIONI, Alessandro, JOYCE, Patrick, ATKINSON, Kelley, JIA, Fang
Format Patent
LanguageEnglish
French
Published 11.01.2024
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Antibodies having enhanced biodistribution and/or pharmacokinetics obtained through disruption of one or more clusters of surface-exposed positively charged amino acids are provided. Also provided are methods of enhancing the biodistribution and/or pharmacokinetics of an antibody. The enhanced antibodies find use in immunotherapy, radiotherapy, and in vivo imaging. L'invention concerne des anticorps ayant une biodistribution et/ou une pharmacocinétique améliorée obtenues par perturbation d'un ou de plusieurs groupes d'acides aminés chargés positivement exposés en surface. L'invention concerne également des procédés d'amélioration de la biodistribution et/ou de la pharmacocinétique d'un anticorps. Les anticorps améliorés trouvent une utilisation en immunothérapie, en radiothérapie et en imagerie in vivo.
Bibliography:Application Number: WO2023US69725