NOVEL TCTP-BINDING MOLECULE

• Main Authors: KIM, Won-Tae, LEE, Gwanghee, JEON, Hyungsu, RYOU, Jeong-Hyun
• Format: Patent
• Language: English; French; Korean
• Published: 11.01.2024
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; TESTING

The present invention relates to a novel binding molecule or fragment thereof that specifically binds to an extracellular translationally controlled tumor protein (TCTP). The present invention relates to a binding molecule or a fragment thereof, and use thereof. The binding molecule and fragment thereof according to the present invention can be used to diagnose, treat or prevent cancer. The binding molecule and fragment thereof according to the present invention can be used to alleviate or prevent immune suppression in a tumor immune microenvironment. The binding molecule and fragment thereof according to the present invention can be used to diagnose, treat or prevent cancer in patients who do not respond, have a limited response, are likely to respond to treatment using a cancer immunotherapeutic agent. La présente invention concerne une nouvelle molécule de liaison ou un fragment de celle-ci qui se lie de manière spécifique à une protéine tumorale à régulation traductionnelle extracellulaire (TCTP). La présente invention concerne une molécule de liaison ou un fragment de celle-ci, et son utilisation. La molécule de liaison et le fragment de celle-ci selon la présente invention peuvent être utilisés pour diagnostiquer, traiter ou prévenir le cancer. La molécule de liaison et le fragment de celle-ci selon la présente invention peuvent être utilisés pour atténuer ou prévenir la suppression immunitaire dans un micro-environnement immunitaire tumoral. La molécule de liaison et le fragment de celle-ci selon la présente invention peuvent être utilisés pour diagnostiquer, traiter ou prévenir un cancer chez des patients qui ne répondent pas, ont une réponse limitée, sont susceptibles de répondre à un traitement à l'aide d'un agent immunothérapeutique anticancéreux. 본 발명은 세포외 TCTP (translationally controlled tumor protein)에 특이적으로 결합하는 신규한 결합분자 또는 그의 단편에 관한 것이다. 본 발명에 따른 결합분자 또는 그의 단편, 및 그의 용도에 관한 것이다. 본 발명에 따른 결합분자 및 그의 단편은 암을 진단, 치료 또는 예방하는데 이용될 수 있다. 본 발명에 따른 결합분자 및 그의 단편은 종양 면역 미세 환경 중 면역 억제를 완화시키거나 예방하는데 이용될 수 있다. 본 발명에 따른 결합분자 및 그의 단편은 면역항암제를 이용한 치료에 반응하지 않거나 제한적으로 반응하였거나, 그러할 가능성이 있는 환자에서 암을 진단하거나 치료하거나 예방하는 데에 이용될 수 있다.