PI3K INHIBITOR, PREPARATION METHOD THEREFOR, AND USE THEREOF

• Main Authors: LIU, Xingtai, WANG, Wenzhong, PENG, Ying, FAN, Lei, LI, Xinghai, XU, Kexin, TAN, Bin, LUO, Yao, WANG, Fei, LUO, Tongchuan, WANG, Xuzhao, AI, Chaowu, LIU, Chengcheng, DU, Jing, LI, Liang, CHEN, Yuanwei, XIAO, Daibiao, YAN, Dejun, YU, Hua
• Format: Patent
• Language: Chinese; English; French
• Published: 11.01.2024
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention belongs to the field of chemical pharmaceuticals, and provided are a PI3K inhibitor, a preparation method therefor, and a use thereof. The PI3K inhibitor of the present invention is a compound as represented by formula I, or a salt thereof, a stereoisomer thereof, a solvate thereof, a hydrate thereof, or a prodrug thereof. The prepared compound can be used for preparing a PI3K selective inhibitor and for preparing a drug for preventing and/or treating a disease related to PI3K, such as a drug for preventing and/or treating cancer. The present invention provides a new choice for clinically treating cancer, and the present invention has good application prospects. La présente invention appartient au domaine des produits pharmaceutiques chimiques, et concerne un inhibiteur de PI3K, un procédé de préparation associé et une utilisation associée. L'inhibiteur de PI3K de la présente invention est un composé tel que représenté par la formule I, ou un sel de celui-ci, un stéréo-isomère de celui-c