COMPOUND COMPRISING SELF-IMMOLATIVE GROUP AND LIGAND-DRUG CONJUGATE COMPRISING SAME

• Main Authors: MIN, Gyoung Wook, CHO, Jong Un, LEE, Hyun Mi, WOO, Sung Ho, PARK, Ok Ku, PARK, Su Ho, YUN, Sang Hyeon
• Format: Patent
• Language: English; French; Korean
• Published: 04.01.2024
• Subjects: CHEMISTRY; DERIVATIVES THEREOF; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SUGARS

The present invention provides a compound comprising a self-immolative group and a ligand-drug conjugate comprising same. According to the present invention, an active material may be stably delivered up to a target site, and the active material may be rapidly released at the target site, thereby in...