COMPOUND COMPRISING SELF-IMMOLATIVE GROUP AND LIGAND-DRUG CONJUGATE COMPRISING SAME

• Main Authors: MIN, Gyoung Wook, CHO, Jong Un, LEE, Hyun Mi, WOO, Sung Ho, PARK, Ok Ku, PARK, Su Ho, YUN, Sang Hyeon
• Format: Patent
• Language: English; French; Korean
• Published: 04.01.2024
• Subjects: CHEMISTRY; DERIVATIVES THEREOF; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SUGARS

The present invention provides a compound comprising a self-immolative group and a ligand-drug conjugate comprising same. According to the present invention, an active material may be stably delivered up to a target site, and the active material may be rapidly released at the target site, thereby increasing the efficacy of the active material, and the active material may be inhibited from causing a side effect at a location other than the target location. La présente invention concerne un composé comprenant un groupe auto-immolable et un conjugué ligand-médicament le comprenant. Selon la présente invention, une substance active peut être administrée de manière stable jusqu'à un site cible, et la substance active peut être rapidement libérée au niveau du site cible, ce qui permet d'augmenter l'efficacité de la substance active, et il est possible d'empêcher que la substance active provoque un effet secondaire dans une zone autre que la zone cible. 본 발명은 자가-희생기를 포함하는 화합물 및 이를 포함하는 리간드-약물 접합체를 제공한다. 이에 의하면, 활성 물질을 안정적으로 표적 부위까지 운반할 수 있으며, 표적 부위에서 활성 물질을 신속히 방출시켜, 활성 물질의 효력을 증가시키고, 활성 물질이 표적 위치 외의 위치에서 부작용을 일으키는 것을 억제할 수 있다.