PH-RESPONSIVE LIPID DERIVATIVE

• Main Authors: GHASEMIZADEH, Aria, OGI, Koichi, NOMOTO, Takahiro, TOYODA, Masahiro, NISHIYAMA, Nobuhiro, SUNG, Yi-Jung, OHTAKE, Tomoyuki, MICHINISHI, Junya, MATSUI, Makoto, TAKEMOTO, Hiroyasu, MIURA, Yutaka
• Format: Patent
• Language: English; French; Japanese
• Published: 12.01.2023
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS BASED THEREON; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONSONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; ORGANIC MACROMOLECULAR COMPOUNDS; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; THEIR PREPARATION OR CHEMICAL WORKING-UP; VINEGAR; WINE

The present invention provides: a pH-responsive lipid derivative represented by the structure shown in a formula (i) (where each symbol in the formula is as defined in the description); and a pH-responsive carrier that is useful as a carrier for safely and efficiently delivering a low-molecular-weight drug and the like to tumor tissue. La présente invention concerne : un dérivé lipidique sensible au pH représenté par la structure représentée dans la formule (i) (chaque symbole dans la formule étant tel que défini dans la description) ; et un support sensible au pH qui est utile en tant que support pour l'administration sûre et efficace d'un médicament à faible poids moléculaire et similaire au tissu tumoral. 本発明は、下記式（ｉ）で表される構造：（上記式中、各記号は明細書に記載のとおりである。） で表されるｐＨ応答性脂質誘導体、および腫瘍組織への低分子薬剤等の送達等を、安全かつ効率よく行うための輸送担体として有用なｐＨ応答性輸送担体を提供する。