PHARMACEUTICAL COMPOSITION CONTAINING CELL-DERIVED NATURAL OR ARTIFICIAL NANOVESICLES LOADED WITH ANTISENSE OLIGONUCLEOTIDE-BASED DRUG

• Main Authors: LEE, Dong-yeol, AHN, Hee-jin, LEE, Jae-yong, LEE, Dae-han, NA, Kyu-heum
• Format: Patent
• Language: English; French; Korean
• Published: 05.01.2023
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to: a pharmaceutical composition which, by loading a nucleic acid-based drug in cell-derived natural or artificial nanovesicles, is capable of introducing the nucleic acid-based drug into cells; and a method for preparing same. According to the present invention, natural or artificial nanovesicles loaded with an antisense oligonucleotide inhibit the proliferation and migration of cancer cells and exhibit the property of increasing drug sensitivity when administered in combination with conventional chemotherapies. La présente invention se rapporte : à une composition pharmaceutique qui, en chargeant un médicament à base d'acide nucléique dans des nanovésicules naturelles ou artificielles dérivées de cellules, est capable d'introduire le médicament à base d'acide nucléique dans des cellules; et à son procédé de préparation. Selon la présente invention, des nanovésicules naturelles ou artificielles chargées avec un oligonucléotide antisens inhibent la prolifération et la migration de cellules cancéreuses et ont pour propriété d'augmenter la sensibilité aux médicaments lorsqu'elles sont administrées en association avec des chimiothérapies classiques. 본 발명은 세포 유래 자연 또는 인공 나노소포체에 핵산 기반 약물을 탑재시킴으로써, 핵산 기반 약물을 세포안으로 도입할 수 있는 약학 조성물 및 이의 제조방법에 관한 것이다. 본 발명에 따라 안티센스 올리고뉴클레오타이드를 탑재한 자연 또는 인공 나노소포체는 암세포의 증식과 이동을 억제하고 기존 화학항암제와의 병용 투여 시 약물 감수성을 증가시키는 특성을 보인다.