DYRK1 INHIBITOR PYRROLO[3,2-C]PYRIDINE DERIVATIVE AND USE THEREOF

• Main Authors: PARK, A Reum, KAWK, Jae Sung, KIM, Ki Young, LEE, Ge Hyeong, LEE, Hyuk, NA, Yun Ju
• Format: Patent
• Language: English; French; Korean
• Published: 05.01.2023
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to: a pyrrolo[3,2-c]pyridine derivative or a pharmaceutically acceptable salt thereof; and a pharmaceutical composition containing same as an active ingredient, wherein the pharmaceutical composition is used to prevent or treat diseases associated with dual-specificity tyrosine phosphorylation-regulated kinase 1a (DYRK1A) or dual-specificity tyrosine phosphorylation-regulated kinase 1b (DYRK1B). La présente invention concerne : un dérivé de pyrrolo[3,2-c]pyridine ou un sel pharmaceutiquement acceptable de celui-ci ; et une composition pharmaceutique le contenant en tant que principe actif, la composition pharmaceutique étant utilisée pour prévenir ou traiter des maladies associées à la kinase 1a régulée par phosphorylation de tyrosine à double spécificité (DYRK1A) ou la kinase 1b régulée par phosphorylation de tyrosine à double spécificité (DYRK1B). 본 발명은 피롤로[3,2-c]피리딘 유도체, 또는 이의 약학적으로 허용가능한 염; 및 이를 유효성분으로 포함하는 DYRK1A(Dual-specificity tyrosine phosphorylation-regulated kinase 1a) 또는 DYRK1B(Dual-specificity tyrosine phosphorylation-regulated kinase 1b) 관련 질환의 예방 또는 치료용 약학적 조성물에 관한 것이다.