TREATMENT OF MS4A4E RELATED DISEASES AND DISORDERS

• Main Authors: CAJES, Brian, VEKICH, John, MCINNES, Gregory, BRUSE, Shannon, GOTTESMAN, Omri, BUSS, Eric, ROZEMA, David, JAKUBOSKY, David
• Format: Patent
• Language: English; French
• Published: 29.02.2024
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

Disclosed herein are MS4A4E inhibitors such as oligonucleotides that target MS4A4E. The oligonucleotide may include a small interfering RNA (siRNA) or an antisense oligonucleotide (ASO). Also provided herein are methods of treating conditions associated with MS4A4E mutations that include providing an MS4A4E inhibitor to a subject. L'invention concerne des inhibiteurs de MS4A4E tels que des oligonucléotides qui ciblent MS4A4E. L'oligonucléotide peut comprendre un petit ARN interférent (ARNsi) ou un oligonucléotide antisens (ASO). L'invention concerne également des procédés de traitement d'états associés à des mutations de MS4A4E qui comprennent la fourniture d'un inhibiteur de MS4A4E à un sujet.