CORONAVIRUS S PROTEIN VARIANT AND USE THEREOF

• Main Authors: LIN, Jinzhong, LU, Jing, TAN, Shudan
• Format: Patent
• Language: Chinese; English; French
• Published: 14.12.2023
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

Provided is an S protein variant, which does not contain a complete cytoplasmic tail domain compared to the S protein of a wild-type coronavirus. Further provided are a nucleic acid molecule encoding the S protein variant, and the use of the S protein variant and the nucleic acid molecule in the preparation of a vaccine. L'invention concerne un variant de protéine S, qui ne contient pas de domaine de queue cytoplasmique complet par rapport à la protéine S d'un coronavirus de type sauvage. L'invention concerne en outre une molécule d'acide nucléique codant pour le variant de protéine S, et l'utilisation du variant de protéine S et de la molécule d'acide nucléique dans la préparation d'un vaccin. 提供了一种S蛋白变体，与野生型冠状病毒的S蛋白相比，其不包含完整的细胞质尾巴结构域。还提供了编码所述S蛋白变体的核酸分子，以及所述S蛋白变体和核酸分子在制备疫苗中的应用。