PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING HYPERTENSIVE DISEASE COMPRISING ISOLATED MITOCHONDRIA AS ACTIVE INGREDIENT

• Main Authors: KANG, Young Cheol, KIM, Chun-Hyung, KIM, Soomin, CUI, Hui Xing, ZHANG, Yin Hua, HAN, Kyuboem
• Format: Patent
• Language: English; French; Korean
• Published: 07.12.2023
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to a pharmaceutical composition for preventing or treating a hypertensive disease, comprising isolated mitochondria as an active ingredient. When the pharmaceutical composition comprising isolated mitochondria as an active ingredient, according to the present invention, is administered to an individual suffering from a hypertensive disease, the blood pressure of the individual can be lowered. In addition, the pharmaceutical composition can restore damaged blood vessels in the placenta of individuals suffering from hypertension in pregnancy among hypertensive diseases. Moreover, the pharmaceutical composition can normalize side effects, such as low fetal weight and fetal growth restriction, due to a hypertensive disease in pregnancy. Therefore, the pharmaceutical composition according to the present invention can be effectively used in the prevention or treatment of hypertensive diseases, particularly hypertension in pregnancy and resistant hypertension. La présente invention concerne une composition pharmaceutique pour la prévention ou le traitement d'une maladie hypertensive, comprenant des mitochondries isolées en tant que principe actif. Lorsque la composition pharmaceutique comprenant des mitochondries isolées en tant que principe actif, selon la présente invention, est administrée à un individu souffrant d'une maladie hypertensive, la pression artérielle de l'individu peut être abaissée. En outre, la composition pharmaceutique peut restaurer les vaisseaux sanguins endommagés dans le placenta d'individus souffrant d'hypertension pendant la grossesse parmi les maladies hypertensives. De plus, la composition pharmaceutique peut normaliser les effets secondaires, tels que le faible poids fœtal et le retard de croissance fœtal, dus à une maladie hypertensive pendant la grossesse. Par conséquent, la composition pharmaceutique selon la présente invention peut être efficacement utilisée dans la prévention ou le traitement de maladies hypertensives, en particulier l'hypertension pendant la grossesse et l'hypertension résistante. 본 발명은 분리된 미토콘드리아를 유효성분으로 포함하는 고혈압성 질환 예방 또는 치료용 약학 조성물에 관한 것이다. 본 발명에 따른 분리된 미토콘드리아를 유효성분으로 포함하는 약학 조성물을 고혈압성 질환을 앓고 있는 개체에 투여할 경우, 개체의 혈압을 강하시킬 수 있다. 뿐만 아니라, 고혈압성 질환 중 임신 중 고혈압을 앓고 있는 개체의 태반내 손상된 혈관을 회복시킬 수 있다. 또한, 임신 중 고혈압성 질환에 따른 태아의 저체중 및 태아성장 제한의 부작용을 정상화시킬 수 있다. 따라서, 본 발명에 따른 약학 조성물은 고혈압성 질환, 특히 임신 중 고혈압, 저항성 고혈압의 예방 또는 치료에 유용하게 사용될 수 있다.