COMPOSITION FOR PREVENTING, IMPROVING, OR TREATING RENAL FIBROSIS COMPRISING ONE OR MORE ACTIVE INGREDIENTS

• Main Authors: SUN, Wenjuan, PARK, Jung Sun, KIM, Soo Wan, KIM, Chang Seong, BAE, Eun Hui, MA, Seong Kwon
• Format: Patent
• Language: English; French; Korean
• Published: 07.12.2023
• Subjects: FOODS OR FOODSTUFFS; FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES

The present invention relates to a pharmaceutical composition for preventing, improving, or treating renal fibrosis, and more specifically, to a pharmaceutical composition and a health functional food for preventing, improving, or treating renal fibrosis comprising one or more active ingredients, wherein it was confirmed that β-elemene and Z-guggulsterone individually or in cooperation with each other inhibit renal fibrosis in renal tubules and renal interstitial fibroblasts, and the present invention was developed using novel uses of β-elemene and Z-guggulsterone. La présente invention concerne une composition pharmaceutique pour la prévention, l'amélioration ou le traitement de la fibrose rénale, et plus spécifiquement, une composition pharmaceutique et un aliment fonctionnel de santé pour la prévention, l'amélioration ou le traitement de la fibrose rénale comprenant un ou plusieurs principes actifs, l'inhibition de la fibrose rénale par des β-élémènes et Z-guggulstérones individuellement ou en coopération l'un avec l'autre ayant été confirmée dans les tubules rénaux et les fibroblastes interstitiels rénaux, et la présente invention a été développée à l'aide de nouvelles utilisations de β-élémènes et de Z-guggulstérone. 본 발명은 신장섬유화증 예방, 개선 또는 치료용 약학조성물에 대한 것으로, 보다 구체적으로는 β-elemene과　Z-guggulsterone이 각각 또는 서로 협력하여 신장　세뇨관과　신장간질　섬유아세포에서 신장섬유화를 억제하는 것을 확인하고 이들의 신규 용도를 활용하여 개발된 1개 이상의 유효성분을 포함하는 신장섬유화증 예방, 개선 또는 치료용 약학조성물 및 건강기능식품에 관한 것이다.