MACROLIDE SENOLYTIC COMPOUNDS
Disclosed herein are macrolide compounds having senolytic activity. These compounds selectively target senescent cells, and may be used to reduce or eradicate senescent cells in a subject, and/or delay the onset of aging. These compounds also inhibit propagation of cancer stem cells, and may be used...
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| Main Authors | , , , |
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| Format | Patent |
| Language | English French |
| Published |
07.12.2023
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Disclosed herein are macrolide compounds having senolytic activity. These compounds selectively target senescent cells, and may be used to reduce or eradicate senescent cells in a subject, and/or delay the onset of aging. These compounds also inhibit propagation of cancer stem cells, and may be used to treat cancer, and in particular inhibit the propagation of cancer stem cells responsible for metastasis and tumor recurrence. Formulae (I) & (II):
La présente divulgation concerne des composés macrolides ayant une activité sénolytique. Ces composés ciblent sélectivement les cellules sénescentes, et peuvent être utilisés pour réduire ou éradiquer des cellules sénescentes chez un sujet, et/ou retarder l'apparition du vieillissement. Ces composés inhibent également la propagation de cellules souches cancéreuses, et peuvent être utilisés pour traiter le cancer, et en particulier inhiber la propagation de cellules souches cancéreuses responsables de la métastase et de la récurrence tumorale. Formules (I) et (II) : |
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| AbstractList | Disclosed herein are macrolide compounds having senolytic activity. These compounds selectively target senescent cells, and may be used to reduce or eradicate senescent cells in a subject, and/or delay the onset of aging. These compounds also inhibit propagation of cancer stem cells, and may be used to treat cancer, and in particular inhibit the propagation of cancer stem cells responsible for metastasis and tumor recurrence. Formulae (I) & (II):
La présente divulgation concerne des composés macrolides ayant une activité sénolytique. Ces composés ciblent sélectivement les cellules sénescentes, et peuvent être utilisés pour réduire ou éradiquer des cellules sénescentes chez un sujet, et/ou retarder l'apparition du vieillissement. Ces composés inhibent également la propagation de cellules souches cancéreuses, et peuvent être utilisés pour traiter le cancer, et en particulier inhiber la propagation de cellules souches cancéreuses responsables de la métastase et de la récurrence tumorale. Formules (I) et (II) : |
| Author | LISANTI, Michael P KANGASMETSA, Jussi SOTGIA, Federica OZSVARI, Béla |
| Author_xml | – fullname: SOTGIA, Federica – fullname: LISANTI, Michael P – fullname: OZSVARI, Béla – fullname: KANGASMETSA, Jussi |
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| DocumentTitleAlternate | COMPOSÉS SÉNOLYTIQUES MACROLIDES |
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| Notes | Application Number: WO2023IB55545 |
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| RelatedCompanies | LUNELLA BIOTECH, INC |
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| Snippet | Disclosed herein are macrolide compounds having senolytic activity. These compounds selectively target senescent cells, and may be used to reduce or eradicate... |
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| SubjectTerms | CHEMISTRY DERIVATIVES THEREOF HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SUGARS |
| Title | MACROLIDE SENOLYTIC COMPOUNDS |
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