MACROLIDE SENOLYTIC COMPOUNDS

Disclosed herein are macrolide compounds having senolytic activity. These compounds selectively target senescent cells, and may be used to reduce or eradicate senescent cells in a subject, and/or delay the onset of aging. These compounds also inhibit propagation of cancer stem cells, and may be used...

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Bibliographic Details
Main Authors SOTGIA, Federica, LISANTI, Michael P, OZSVARI, Béla, KANGASMETSA, Jussi
Format Patent
LanguageEnglish
French
Published 07.12.2023
Subjects
CHEMISTRY
DERIVATIVES THEREOF
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SUGARS
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Summary:Disclosed herein are macrolide compounds having senolytic activity. These compounds selectively target senescent cells, and may be used to reduce or eradicate senescent cells in a subject, and/or delay the onset of aging. These compounds also inhibit propagation of cancer stem cells, and may be used to treat cancer, and in particular inhibit the propagation of cancer stem cells responsible for metastasis and tumor recurrence. Formulae (I) & (II): La présente divulgation concerne des composés macrolides ayant une activité sénolytique. Ces composés ciblent sélectivement les cellules sénescentes, et peuvent être utilisés pour réduire ou éradiquer des cellules sénescentes chez un sujet, et/ou retarder l'apparition du vieillissement. Ces composés inhibent également la propagation de cellules souches cancéreuses, et peuvent être utilisés pour traiter le cancer, et en particulier inhiber la propagation de cellules souches cancéreuses responsables de la métastase et de la récurrence tumorale. Formules (I) et (II) :
Bibliography:Application Number: WO2023IB55545