PHARMACEUTICAL COMBINATION AND PHARMACEUTICAL COMPOSITION FOR TREATING CANCER

• Main Authors: DAN, Mo, ZHANG, Hancheng, LIU, Xibao, WU, Xiaojuan, LI, Yanling, LIU, Jieru, CAI, Congcong, YANG, Hanyu
• Format: Patent
• Language: Chinese; English; French
• Published: 07.12.2023
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Provided are a pharmaceutical combination and a pharmaceutical composition comprising a compound of formula (I) or a pharmaceutically acceptable form thereof and at least one other anticancer agent, and use thereof in the preparation of a drug for treating malignant tumor diseases. The other anti-cancer agent is a CDK inhibitor or a pharmaceutically acceptable salt thereof (such as piperitracin), lenvatinib or a pharmaceutically acceptable salt thereof, sorafenib or a pharmaceutically acceptable salt thereof, or any combination of the above. L'invention concerne une association pharmaceutique et une composition pharmaceutique comprenant un composé de formule (I) ou une forme pharmaceutiquement acceptable de celui-ci et au moins un autre agent anticancéreux, et son utilisation dans la préparation d'un médicament pour le traitement de maladies tumorales malignes. L'autre agent anticancéreux est un inhibiteur de CDK ou un sel pharmaceutiquement acceptable de celui-ci (tel que la pipérazine), le lenvatinib ou un