TREATMENT OF SOS2 RELATED DISEASES AND DISORDERS

Disclosed herein are compositions comprising an oligonucleotide that targets SOS Ras/Rho guanine nucleotide exchange factor 2 (SOS2). The oligonucleotide may include a small interfering RNA (siRNA) or an antisense oligonucleotide (ASO). Also provided herein are methods of treating conditions associa...

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Bibliographic Details
Main Authors CAJES, Brian, VEKICH, John, MCINNES, Gregory, BRUSE, Shannon, GOTTESMAN, Omri, ROZEMA, David, JAKUBOSKY, David, LEWIS, David
Format Patent
LanguageEnglish
French
Published 30.11.2023
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:Disclosed herein are compositions comprising an oligonucleotide that targets SOS Ras/Rho guanine nucleotide exchange factor 2 (SOS2). The oligonucleotide may include a small interfering RNA (siRNA) or an antisense oligonucleotide (ASO). Also provided herein are methods of treating conditions associated with SOS2 mutations that include providing an oligonucleotide that targets SOS2 to a subject. L'invention concerne des compositions comprenant un oligonucléotide qui cible le facteur d'échange nucléotidique 2 de SOS Ras/Rho guanine (SOS2). L'oligonucléotide peut comprendre un petit ARN interférent (ARNsi) ou un oligonucléotide antisens (ASO). L'invention concerne également des procédés de traitement d'états associés à des mutations de SOS2 qui comprennent la fourniture d'un oligonucléotide qui cible SOS2 sur un sujet.
Bibliography:Application Number: WO2023US67360