INFECTIOUS FULL-LENGTH CLONE OF ZIKA VIRUS OR VARIANT THEREOF AND USE THEREOF

• Main Authors: OH, Jong-Won, JUNG, Hae-Gwang, CHO, Hee
• Format: Patent
• Language: English; French; Korean
• Published: 30.11.2023
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPOSITIONS THEREOF; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES OF PREPARING SUCH COMPOSITIONS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

An aspect pertains to an infectious full-length clone of Zika virus or a variant thereof, and a use thereof. According to an aspect, a full-length clone of Zika virus or a derivative thereof, containing a T7 bacteriophage promoter, can be utilized to analyze the replication mechanism, life cycle, and pathogenicity of Zika virus. Hence, the clone can be beneficially employed for screening a drug for prevention or treatment of Zika virus infection and for evaluating the efficacy of diagnostic techniques. The genetic material, proteins, or fragments of Zika virus, restored from the clone or a derivative thereof, can be usefully employed as vaccines for preventing Zika virus infections. Un aspect concerne un clone infectieux pleine longueur du virus Zika ou d'un de ses variants, ainsi que son utilisation. Selon un aspect, un clone pleine longueur du virus Zika ou d'un de ses dérivés, contenant un promoteur de bactériophage T7, peut être utilisé pour analyser le mécanisme de réplication, le cycle de vie et la pathogénicité du virus Zika. Par conséquent, le clone peut être avantageusement utilisé pour cribler un médicament pour la prévention ou le traitement d'une infection par le virus Zika et pour évaluer l'efficacité de techniques de diagnostic. Le matériau génétique, les protéines ou les fragments du virus Zika, restaurés à partir du clone ou d'un dérivé de celui-ci, peuvent être utilisés utilement en tant que vaccins pour prévenir des infections par le virus Zika. 일 양상은 지카바이러스 감염성 전장 클론 또는 이의 변이체 및 이들의 용도에 관한 것이다. 일 양상에 따르면, T7 박테리아 파지 프로모터를 포함하는 지카바이러스의 전장 클론 또는 이의 유도체는 지카바이러스의 복제 기작, 생활사 및 병원성 분석에 활용될 수 있다. 따라서, 상기 클론은 지카바이러스 감염증 예방 또는 치료용 약제의 스크리닝 및 진단 기술의 유효성 평가에 유용하게 활용될 수 있으며, 상기 클론 또는 이의 유도체로부터 복원되는 지카바이러스의 유전 물질, 단백질 또는 이들의 단편은 지카바이러스 예방용 백신으로 유용하게 활용될 수 있다.