USING FUNGAL CONSTRUCTS TO PRODUCE VIRAL PROTEIN ANTIGENS

• Main Authors: FINGER, Avner, KOVALCHUK, Andriy, TCHELET, Ronen, MARKKU, Saloheimo, ZRACHYA, Avi, VALBUENA, Noelia
• Format: Patent
• Language: English; French
• Published: 23.11.2023
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

The present disclosure concerns using transgenic fungus to express recombinant viral antigens. The composition, production, and administration of vaccines comprising those viral antigens also are disclosed. In some embodiments, these viral antigens can be used to formulate a vaccine against Newcastle Disease. These vaccines can be administered, for example, via intramuscular injection. La présente divulgation concerne l'utilisation d'un champignon transgénique pour exprimer des antigènes viraux recombinants. La présente divulgation concerne également la composition, la production et l'administration de vaccins comprenant ces antigènes viraux. Selon certains modes de réalisation, ces antigènes viraux peuvent être utilisés pour formuler un vaccin contre la maladie de Newcastle. Ces vaccins peuvent être administrés, par exemple, par injection intramusculaire.