FORMULATIONS FOR ADMINISTERING LAAM, norLAAM AND dinorLAAM AND METHODS OF THEIR USE TO TREAT OPIOID USE DISORDER

Rapid-release formulations for administering Levo-alpha-acetylmethadol (LAAM), norLAAM and dinorLAMM and, optionally, magnesium, are provided. The formulations include solid i) core-shell oral dosage forms delivered in capsules or tablets, and ii) electrospun nano/microfiber buccal film dosage forms...

Full description

Saved in:
Bibliographic Details
Main Authors O'KEEFFE, Charles, SUDARJAT, Hadi, LU, Xiuling, RAYNOLD, Aji, ZHEN, Zixuan, BERINGHS, André, XU, Qingguo
Format Patent
LanguageEnglish
French
Published 23.11.2023
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Online AccessGet full text

Cover

More Information
Summary:Rapid-release formulations for administering Levo-alpha-acetylmethadol (LAAM), norLAAM and dinorLAMM and, optionally, magnesium, are provided. The formulations include solid i) core-shell oral dosage forms delivered in capsules or tablets, and ii) electrospun nano/microfiber buccal film dosage forms. Methods of the use of the formulations to treat opioid use disorder (OUD) and pain are also provided. L'invention concerne des formulations à libération rapide permettant d'administrer du lévo-alpha-acétylméthadol (LAAM), du norLAAM et du dinorLAMM et, éventuellement, du magnésium. Les formulations comprennent i) des formes posologiques orales cœur-écorce administrées dans des capsules ou des comprimés, et ii) des formes posologiques de film buccal nano/microfibre électrofilées. L'invention concerne également des procédés d'utilisation des formulations pour traiter des troubles liés à l'utilisation d'opioïdes (OUD) et la douleur.
Bibliography:Application Number: WO2023US67216