MACROCYCLES AS LRRK2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF

• Main Authors: YAN, Xin, PALTE, Rachel, ZHOU, Hua, ARDOLINO, Michael, XIAO, Dong, KEYLOR, Mitchell, GULATI, Anmol, KATTAR, Solomon, LOGAN, Kaitlyn, POREMBA, Kelsey, YU, Elsie, FULLER, Peter
• Format: Patent
• Language: English; French
• Published: 23.11.2023
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The present invention is directed to certain 2-aminoquinzaoline derivatives of Formula (I) and (Ia): and pharmaceutically acceptable salts thereof, which are potent inhibitors of LRRK2 kinase and may be useful in the treatment or prevention of diseases in which the LRRK2 kinase is involved, such as Parkinson's Disease and other diseases and disorders described herein. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which LRRK-2 kinase is involved. La présente invention concerne certains dérivés de 2-aminoquinzaoline de formules I et Ia et des sels pharmaceutiquement acceptables de ceux-ci, qui sont de puissants inhibiteurs de la kinase LRRK2 et peuvent être utiles dans le traitement ou la prévention de maladies dans lesquelles la kinase LRRK2 est impliquée, telles que la maladie de Parkinson et d'autres maladies et troubles décrits ici. L'invention concerne également des compositions pharmaceutiques comportant lesdits composés et l'utilisation de ces composés et compositions dans la prévention ou le traitement de maladies dans lesquelles la kinase LRRK2 est impliquée.