AZOLO COMPOUNDS FOR TREATMENT OF FIBROTIC DISEASES

The present invention relates to an azolo compound of Formula (I) for use in the treatment of fibrosis, wherein the azolo compounds normalizes collagen I mRNA-levels of TGFB-activated fibroblasts and reverses collagen production to the normal levels that are seen in fibroblasts that are not stimulat...

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Bibliographic Details
Main Authors VOSS, Edgar, HASENFUSS, Gerd, NYAMSUREN, Gunsmaa, TIETZE, Lutz Friedjahn, MOTHUKU, Shyam Sundar, ZEISBERG, Michael
Format Patent
LanguageEnglish
French
Published 23.11.2023
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention relates to an azolo compound of Formula (I) for use in the treatment of fibrosis, wherein the azolo compounds normalizes collagen I mRNA-levels of TGFB-activated fibroblasts and reverses collagen production to the normal levels that are seen in fibroblasts that are not stimulated. La présente invention concerne un composé azolo de Formule (I) destiné à être utilisé dans le traitement de la fibrose, les composés azolo normalisant les taux d'ARNm de collagène I de fibroblastes activés par TGFB et inversant la production de collagène vers les niveaux normaux qui sont constatés dans des fibroblastes qui ne sont pas stimulés.
Bibliography:Application Number: WO2023EP63457