INHIBITORS OF KRAS(G12D)

Provided are small molecule inhibitors of the KRAS (G12D) mutant oncoprotein having the structural formula: R00F2C-L-R0 and pharmaceutically acceptable salts and compositions thereof, which are useful for treating cancers and related conditions. L'invention concerne des inhibiteurs à petites mo...

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Main Authors WANG, Guoqiang, YIN, Wei, DAI, Yan, WANG, Zhiyong, YING, Weiwen, YING, Chenghao, PRINCE, Thomas, FOLEY, Kevin, WANG, Yaya
Format Patent
LanguageEnglish
French
Published 16.11.2023
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Provided are small molecule inhibitors of the KRAS (G12D) mutant oncoprotein having the structural formula: R00F2C-L-R0 and pharmaceutically acceptable salts and compositions thereof, which are useful for treating cancers and related conditions. L'invention concerne des inhibiteurs à petites molécules de l'oncoprotéine mutante KRAS (G12D) ayant la formule structurale : R00F2C-L-R0 et des sels pharmaceutiquement acceptables et des compositions de ceux-ci, qui sont utiles pour le traitement de cancers et d'états associés.
Bibliography:Application Number: WO2023US22116