LIQUID ANTIBODY COMPOSITION AND USE THEREOF

• Main Authors: ZHANG, Yanzhen, WANG, An, LI, Gang, TANG, Peipei, XIONG, Wenrui, JI, Shuangyi
• Format: Patent
• Language: Chinese; English; French
• Published: 16.11.2023
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

Disclosed in the present invention are a liquid antibody composition and the use thereof. The liquid antibody composition comprises a bispecific antibody targeting PD-L1 and CD47, an acidic buffer solution, a saccharide stabilizer and a polysorbate surfactant, and has a pH of 5.5-6.5, preferably 5.5-6.0. The composition has a good stability under the conditions of a high-concentration bispecific antibody. La présente invention concerne une composition d'anticorps liquide et son utilisation. La composition d'anticorps liquide comprend un anticorps bispécifique ciblant PD-L1 et CD47, une solution tampon acide, un stabilisant de saccharide et un tensioactif de polysorbate, et présente un pH de 5,5 à 6,5, de préférence de 5,5 à 6,0. La composition présente une bonne stabilité dans les conditions d'un anticorps bispécifique à haute concentration. 本发明公开了液体抗体组合物及其应用，其中，该液体抗体组合物包括：靶向PD-L1和CD47的双特异性抗体；酸性缓冲液；糖类稳定剂；聚山梨酯类表面活性剂；且pH为5.5-6.5，优选地，为5.5-6.0。该组合物在高浓度双特异抗体条件下具有良好的稳定性。