SPLIT MODIFIED DEHALOGENASE VARIANTS

Provided herein are peptide and polypeptide sequences that structurally assemble to form active, modified dehalogenase structures capable of binding to a haloalkyl ligand. In particular, provided herein are split dehalogenase variants that assemble through structural complementation into active deha...

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Bibliographic Details
Main Authors GLASGOW, Evan, ESMATPOUR, Rahele, KILLORAN, Michael P, KIRKLAND, Thomas, ENCELL, Lance P
Format Patent
LanguageEnglish
French
Published 09.11.2023
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PHYSICS
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
TESTING
VINEGAR
WINE
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Summary:Provided herein are peptide and polypeptide sequences that structurally assemble to form active, modified dehalogenase structures capable of binding to a haloalkyl ligand. In particular, provided herein are split dehalogenase variants that assemble through structural complementation into active dehalogenase complexes, and systems and methods of use thereof. L'invention concerne des séquences peptidiques et polypeptidiques qui s'assemblent structurellement pour former des structures de déshalogénase modifiées actives pouvant se lier à un ligand haloalkyle. En particulier, l'invention concerne des variants de déshalogénase divisés qui s'assemblent par complémentation structurale en complexes de déshalogénase active, ainsi que des systèmes et des procédés d'utilisation de ceux-ci.
Bibliography:Application Number: WO2023US20959