BICYCLIC PIPERAZINONES AND THERAPEUTIC USES THEREOF

Provided herein are compounds of formula (I): or a pharmaceutically acceptable salt thereof, wherein Z1, Z2, Z3, R1, R2, R3, and n are as defined herein. Also provided herein is a pharmaceutically acceptable composition comprising a compound of formula (I), or a pharmaceutically acceptable salt ther...

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Bibliographic Details
Main Authors KUROSAKI, Toshio, MAKINO, Takuya, HONJO, Eriko, EVANS, Chris, KOIZUMI, Yuka, COLLIBEE, Scott, MORGAN, Bradley P
Format Patent
LanguageEnglish
French
Published 09.11.2023
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Provided herein are compounds of formula (I): or a pharmaceutically acceptable salt thereof, wherein Z1, Z2, Z3, R1, R2, R3, and n are as defined herein. Also provided herein is a pharmaceutically acceptable composition comprising a compound of formula (I), or a pharmaceutically acceptable salt thereof. Also provided herein are methods of using a compound of formula (I), or a pharmaceutically acceptable salt thereof, to treat various diseases, disorders, and conditions responsive to the modulation of the contractility of the skeletal sarcomere. L'invention concerne des composés de formule (I) : ou un sel pharmaceutiquement acceptable de ceux-ci, Z1, Z2, Z3, R1, R2, R3 et n étant tels que définis dans la description. L'invention concerne également une composition pharmaceutiquement acceptable comprenant un composé de formule (I), ou un sel pharmaceutiquement acceptable de celui-ci. L'invention concerne également des procédés d'utilisation d'un composé de formule (I), ou d'un sel pharmaceutiquement acceptable de celui-ci, pour traiter diverses maladies, troubles et états en réponse à la modulation de la contractilité du sarcomère squelettique.
Bibliography:Application Number: WO2023US20814