COMPOSITIONS AND METHODS FOR TREATMENT OF INFLAMMATORY BOWEL DISEASE

The invention relates to the unexpected discovery that the oral administration of charged sodium channel blockers, also called "Nocions," alleviates inflammation in intestinal inflammatory diseases, such as inflammatory bowel disease (IBD), ulcerative colitis and/or Crohn's Disease, w...

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Bibliographic Details
Main Authors ELLIS, James, COLE, Bridget
Format Patent
LanguageEnglish
French
Published 09.11.2023
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention relates to the unexpected discovery that the oral administration of charged sodium channel blockers, also called "Nocions," alleviates inflammation in intestinal inflammatory diseases, such as inflammatory bowel disease (IBD), ulcerative colitis and/or Crohn's Disease, without substantial systemic exposure, as evidenced by low plasma concentrations. The formulations are engineered as an enteric coated tablet to release the composition at a selected location of the bowel. L'invention concerne la découverte inattendue que l'administration orale de bloqueurs de canaux sodiques chargés, également appelés "Notions", atténue l'inflammation dans des maladies inflammatoires intestinales, telles que la MICI, la colite ulcéreuse et/ou la maladie de Crohn, sans exposition systémique substantielle, comme mis en évidence par de faibles concentrations de plasma. Les formulations sont conçues sous forme de comprimés à enrobage entérique pour libérer la composition à un endroit précis de l'intestin.
Bibliography:Application Number: WO2023US20681