COMPOUND INCLUDING 2,4-DIAMINOPYRIDINE, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT FOR PREVENTION OR TREATMENT OF CANCER

• Main Authors: AHN, Min Jeong, KIM, Pil Ho, KIM, Eun Hye, KIM, Seong Hwan
• Format: Patent
• Language: English; French; Korean
• Published: 09.11.2023
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to an isobenzofuran-1(3H)-one derivative, which is a kinase inhibitor, and a use thereof and, more specifically, to an isobenzofuran-1(3H)-one derivative having HPK1 inhibitory activity and MLK3 inhibitory activity and a pharmaceutical composition containing same for preventing or treating cancer, virus infectious diseases, Parkinson's disease, non-alcoholic steatohepatitis, or tuberculosis. In addition, the compound can be advantageously used as a composition for prevention or treatment of cancer as it is administered in combination with an anticancer agent or a cell therapy product. La présente invention concerne un dérivé d'isobenzofuran-1(3H)-one, qui est un inhibiteur de kinase, et son utilisation et, plus particulièrement, un dérivé d'isobenzofuran-1(3H)-one ayant une activité inhibitrice de HPK1 et une activité inhibitrice de MLK3 et une composition pharmaceutique le contenant pour prévenir ou traiter le cancer, des maladies infectieuses virales, la maladie de Parkinson, la stéatohépatite non alcoolique ou la tuberculose. De plus, le composé peut être utilisé de manière avantageuse en tant que composition pour prévenir ou traiter le cancer lorsqu'il est administré en combinaison avec un agent anticancéreux ou un produit de thérapie cellulaire. 본 발명은 키나제 억제제인 아이소벤조퓨란-1(3H)-온 유도체 및 이의 용도에 관한 것으로, 보다 구체적으로는 HPK1 저해 활성 및 MLK3 저해 활성을 갖는 아이소벤조퓨란-1(3H)-온 유도체 및 이를 포함하는 암, 바이러스 감염 질환, 파킨슨병, 비알코올성지방간염 또는 결핵의 예방 또는 치료용 약학 조성물로 유용하다. 또한 상기 화합물은 항암제 약물과 병용투여하거나 세포 치료제와 병용투여를 포함하여 암 예방 또는 치료용 조성물로 유용하게 사용 가능하다.