COMPOSITION FOR REGULATING CAR-T CELL ACTIVATION, HEMATOPOIETIC STEM CELL PROLIFERATION, AND iPS CELL DIFFERENTIATION, AND USE THEREOF

• Main Authors: KIDA Katsuhiko, HANAYAMA Rikinari, NISHINO Taito, MATOBA Kazutaka, ANNO Shiho, YAMANO Tomoyoshi
• Format: Patent
• Language: English; French; Japanese
• Published: 02.11.2023
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

Provided are [0] extracellular vesicles that present at least one cytokine extramembranously; [1] extracellular vesicles that present at least one target factor extramembranously; or [2] extracellular vesicles that present at least one target factor and at least one cytokine extramembranously. L'invention concerne [0] des vésicules extracellulaires qui présentent au moins une cytokine en extramembranaire; [1] des vésicules extracellulaires qui présentent au moins un facteur cible en extramembranaire; ou [2] des vésicules extracellulaires qui présentent au moins un facteur cible et au moins une cytokine en extramembranaire. [０]　少なくとも１種のサイトカインを膜外に提示する細胞外小胞；　[１]　少なくとも１種のターゲット因子を膜外に提示する細胞外小胞；又は　[２]　少なくとも１種のターゲット因子及び少なくとも１種のサイトカインを膜外に提示する細胞外小胞を提供する。