DIDEHYDRO-3'-DEOXY-4'-ETHYNYLTHYMIDINES AND RELATED COMPOUNDS AND THEIR USE IN TREATING MEDICAL CONDITIONS

The invention provides substituted 2',3'-didehydro-3'-deoxy-4'-ethynylthymidines and related compounds, pharmaceutical compositions, their use for inhibiting LINE1 reverse transcriptase activity, their use for inhibiting HERV-K reverse transcriptase activity, and their use in the...

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Bibliographic Details
Main Authors KAPELLER-LIBERMANN, Rosana, ROMERO, Donna L, BISACCHI, Gregory Stuart, HAYDAR, Simon Nicolas, ZALLER, Dennis
Format Patent
LanguageEnglish
French
Published 26.10.2023
Subjects
CHEMISTRY
DERIVATIVES THEREOF
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SUGARS
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Summary:The invention provides substituted 2',3'-didehydro-3'-deoxy-4'-ethynylthymidines and related compounds, pharmaceutical compositions, their use for inhibiting LINE1 reverse transcriptase activity, their use for inhibiting HERV-K reverse transcriptase activity, and their use in the treatment of medical disorders, such as cancer. L'invention concerne des 2',3'-didéhydro-3'-désoxy-4'-éthynylthymidines substituées et des composés apparentés, des compositions pharmaceutiques, leur utilisation pour inhiber l'activité de la transcriptase inverse LINE1, leur utilisation pour inhiber l'activité de la transcriptase inverse HERV-K, et leur utilisation dans le traitement de troubles médicaux, tels que le cancer.
Bibliography:Application Number: WO2023US66074