COMPOSITIONS AND METHODS FOR DISRUPTING PATHOLOGICAL AGGREGATES

The present disclosure provides methods of disrupting a protein aggregate modified with branched polyubiquitin, contacting the protein aggregate with an agent that promotes binding of a p97/VCP polypeptide to the protein aggregate to disrupt the protein aggregate, and further, treating diseases, suc...

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Bibliographic Details
Main Authors SEE, Stephanie Kum-Yin, RAPE, Michael, SCHALETZKY, Julia Sabine, WEHRI, Edward Eric
Format Patent
LanguageEnglish
French
Published 26.10.2023
Subjects
HUMAN NECESSITIES
HYGIENE
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
MEDICAL OR VETERINARY SCIENCE
PHYSICS
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
TESTING
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Summary:The present disclosure provides methods of disrupting a protein aggregate modified with branched polyubiquitin, contacting the protein aggregate with an agent that promotes binding of a p97/VCP polypeptide to the protein aggregate to disrupt the protein aggregate, and further, treating diseases, such as neurodegenerative diseases, associated with a protein aggregate. La présente divulgation concerne des procédés de dislocation d'un agrégat de protéines comprenant de la polyubiquitine ramifiée. La présente divulgation concerne une méthode de traitement d'une maladie associée à un agrégat de protéines comprenant de la polyubiquitine ramifiée.
Bibliography:Application Number: WO2023US65671