COMPOSITIONS AND METHODS FOR DISRUPTING PATHOLOGICAL AGGREGATES

The present disclosure provides methods of disrupting a protein aggregate modified with branched polyubiquitin, contacting the protein aggregate with an agent that promotes binding of a p97/VCP polypeptide to the protein aggregate to disrupt the protein aggregate, and further, treating diseases, suc...

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Bibliographic Details
Main Authors SEE, Stephanie Kum-Yin, RAPE, Michael, SCHALETZKY, Julia Sabine, WEHRI, Edward Eric
Format Patent
LanguageEnglish
French
Published 26.10.2023
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Summary:The present disclosure provides methods of disrupting a protein aggregate modified with branched polyubiquitin, contacting the protein aggregate with an agent that promotes binding of a p97/VCP polypeptide to the protein aggregate to disrupt the protein aggregate, and further, treating diseases, such as neurodegenerative diseases, associated with a protein aggregate. La présente divulgation concerne des procédés de dislocation d'un agrégat de protéines comprenant de la polyubiquitine ramifiée. La présente divulgation concerne une méthode de traitement d'une maladie associée à un agrégat de protéines comprenant de la polyubiquitine ramifiée.
Bibliography:Application Number: WO2023US65671