NOVEL SOLID STATE FORMS OF VOXELOTOR AND THEIR PREPARATION METHODS THEREOF

The present invention relates to novel solid-state forms of Voxelotor of formula-1 and their preparation methods thereof. The Voxelotor of formula-1 is represented by the following structural formula. The present invention also related to an improved process for the preparation of the 2- hydroxy-6-(...

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Bibliographic Details
Main Authors GIDDALAPATI, Srinivas Reddy, DODLE, Beerappa, SAGYAM, Rajeshwar Reddy, KAMMARI, Balraju, SALADI, Venkata Narasayya, SRINIVASAN, Thirumalai Rajan, SAJJA, Eswaraiah, MATHAD, Vijayavitthal T, SHAIK, Mohammad Rafee
Format Patent
LanguageEnglish
French
Published 19.10.2023
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention relates to novel solid-state forms of Voxelotor of formula-1 and their preparation methods thereof. The Voxelotor of formula-1 is represented by the following structural formula. The present invention also related to an improved process for the preparation of the 2- hydroxy-6-(methoxymethoxy)benzaldehyde of formula-5 which is a key intermediate of Voxelotor of formula-1. La présente invention concerne de nouvelles formes à l'état solide de voxélotor de formule-1 et leurs procédés de préparation. Le voxélotor de formule-1 est représenté par la formule développée suivante. La présente invention concerne également un procédé amélioré pour la préparation du 2-hydroxy-6-(méthoxyméthoxy)benzaldéhyde de formule-5 qui est un intermédiaire clé du voxélotor de formule-1.
Bibliography:Application Number: WO2023IN50337