METHODS FOR TREATING DISORDERS AMELIORATED BY MUSCARINIC RECEPTOR ACTIVATION

Provided herein is a method for treating a disorder ameliorated by muscarinic receptor activation in a patient in need thereof, comprising administering to the patient a muscarinic orthosteric agonist, such as xanomeline and/or a salt thereof and an M1 or M4 muscarinic positive allosteric modulator...

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Bibliographic Details
Main Authors YOHN, Samantha, PAUL, Steven, FELDER, Christian, POPIOLEK, Michael, MONN, James Allen
Format Patent
LanguageEnglish
French
Published 12.10.2023
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Provided herein is a method for treating a disorder ameliorated by muscarinic receptor activation in a patient in need thereof, comprising administering to the patient a muscarinic orthosteric agonist, such as xanomeline and/or a salt thereof and an M1 or M4 muscarinic positive allosteric modulator (PAM). Related pharmaceutical compositions are also provided. L'invention concerne un procédé de traitement d'un trouble soulagé par l'activation du récepteur muscarinique chez un patient en ayant besoin, comprenant l'administration au patient d'un agoniste orthostérique muscarinique, tel que la xanoméline et/ou un sel de celle-ci et un modulateur allostérique positif muscarinique M1 ou M4 (PAM). L'invention concerne également des compositions pharmaceutiques associées.
Bibliography:Application Number: WO2023US65498