PHARMACEUTICAL COMPOSITION FOR CANCER TREATMENT, COMPRISING MUTANT RON INHIBITOR AND ANTI-PD-1 ANTIBODY

• Main Authors: KIM, Hyo-Jin, LEE, Mi-So, KIM, Ha-Na, SHIN, Won-Hwa, SON, Hye-Jin, LEE, Jun-Hyung
• Format: Patent
• Language: English; French; Korean
• Published: 12.10.2023
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to a pharmaceutical composition for cancer prevention or treatment, comprising a mutant RON inhibitor or a pharmaceutically acceptable salt thereof, and to a pharmaceutical composition and a use thereof, the pharmaceutical composition being administered by having a mutant RON inhibitor or a pharmaceutically acceptable salt thereof combined with an anti-PD-1 antibody. La présente invention concerne une composition pharmaceutique pour la prévention ou le traitement du cancer, comprenant un inhibiteur de RON mutant ou un sel pharmaceutiquement acceptable de celui-ci, et une composition pharmaceutique et une utilisation de celle-ci, la composition pharmaceutique étant administrée en ayant un inhibiteur de RON mutant ou un sel pharmaceutiquement acceptable de celui-ci combiné à un anticorps anti-PD-1. 본 발명은 돌연변이형 RON 저해제, 또는 이의 약학적으로 허용 가능한 염을 포함하는 암 예방 또는 치료용 약학 조성물로서, 상기 돌연변이형 RON 저해제, 또는 이의 약학적으로 허용 가능한 염이 항-PD-1 항체와 조합하여 투여되는, 약학 조성물 및 이의 용도에 관한 것이다.