COMPOSITION FOR PREVENTION, AMELIORATION OR TREATMENT OF ASTHMA CONTAINING MALUS BACCATA VAR. MANDSHURICA EXTRACT AS ACTIVE INGREDIENT

• Main Authors: SHON, Eun Jin, JEONG, Soo-Jin, LEE, Meeyoung, BANG, Jihye, KIM, Jinhee, JEON, Woo-Young, JIN, Seong Eun
• Format: Patent
• Language: English; French; Korean
• Published: 12.10.2023
• Subjects: FODDER; FOODS OR FOODSTUFFS; FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES

The present invention relates to a composition for the prevention, amelioration or treatment of asthma, containing a Malus baccata var. mandshurica extract as an active ingredient. The Malus baccata var. mandshurica extract, which is an active ingredient of the present invention, has the effects of reducing the number of inflammatory cells in an asthma animal model, reducing IgE content in the bronchoalveolar lavage fluid (BALF) and plasma of an asthma animal model, reducing IL-13 content in the BALF of an asthma animal model, reducing the hyperplasia of mucus-secreting cells due to infiltration of inflammatory cells into lung tissue or bronchial remodeling and the amount of mucus, and reducing the activity of β-hexosaminidase in mast cells with induced degranulation, and thus can be effectively used as a therapeutic agent for asthma and a material of a health functional food for ameliorating asthma. La présente invention concerne une composition de prévention, d'amélioration ou de traitement de l'asthme, contenant un extrait de Malus baccata var. mandshurica comme principe actif. L'extrait de Malus baccata var. mandshurica, qui est un principe actif de la présente invention, présente les effets de réduire le nombre de cellules inflammatoires dans un modèle animal asthmatique, de réduire la teneur en IgE dans le fluide de lavage bronchoalvéolaire (BALF) et le plasma d'un modèle animal asthmatique, de réduire la teneur en IL-13 dans le BALF d'un modèle animal asthmatique, de réduire l'hyperplasie des cellules sécrétant du mucus dû à l'infiltration des cellules inflammatoires dans le tissu pulmonaire ou le remodelage bronchique et la quantité de mucus, et de réduire l'activité de la β-hexosaminidase dans des mastocytes présentant une dégranulation induite, et peut ainsi être efficacement utilisé comme agent thérapeutique contre l'asthme et matériau d'aliment fonctionnel de santé pour améliorer l'asthme. 본 발명은 털야광나무 추출물을 유효성분으로 함유하는 천식의 예방, 개선 또는 치료용 조성물에 관한 것으로, 본 발명의 유효성분인 털야광나무 추출물은 천식 동물모델에서 염증 세포 수를 감소시키고, 천식 동물모델의 BALF(기관지폐포세척액) 및 혈장에서 IgE 함량을 감소시키고, 천식 동물모델의 BALF 내 IL-13의 함량을 감소시키고, 폐 조직 내 염증 세포들의 침윤 또는 기관지 재형성으로 인한 점액분비 세포의 과형성 및 점액의 양을 감소시키며, 탈과립이 유도된 비만세포의 β-헥소사미니다아제의 활성을 감소시키는 효과가 있으므로, 천식의 치료제, 천식 개선용 건강기능식품의 소재로 유용하게 사용될 수 있다.