MRNA CAP ANALOG AND USES THEREOF

• Main Authors: NOH, Jin Mi, JUNG, Yong Gyu, CHOI, Bo Sung, MIN, Su Hyeon, KIM, Na Ri
• Format: Patent
• Language: English; French; Korean
• Published: 05.10.2023
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; DERIVATIVES THEREOF; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; SUGARS; VINEGAR; WINE

One aspect relates to a compound of chemical formula 1, a cap analog comprising same, mRNA 5'-capped with the cap analog, a method for preparing mRNA by using the cap analog, a use for using the cap analog for preparing mRNA, and a pharmaceutical composition for expressing a desired peptide or protein comprising mRNA 5'-capped with the cap analog. Selon un aspect, l'invention concerne un composé de formule chimique 1, un analogue de coiffe le comprenant, un ARNm 5'-coiffé avec l'analogue de coiffe, un procédé de préparation d'ARNm à l'aide de l'analogue de coiffe, une utilisation pour utiliser l'analogue de coiffe pour la préparation d'ARNm, et une composition pharmaceutique pour exprimer un peptide ou une protéine souhaité comprenant l'ARNm 5'-coiffé avec l'analogue de coiffe. 일 양상은 화학식 1의 화합물, 이를 포함하는 캡 유사체, 그 캡 유사체로 5'캡핑된 mRNA, 그 캡 유사체를 이용한 mRNA 제조방법, 그 캡 유사체를 mRNA 제조에 사용하기 위한 용도, 및 그 캡 유사체로 5'캡핑된 mRNA를 포함하는 목적하는 펩티드 또는 단백질 발현을 위한 약학 조성물 등에 관한 것이다.