SYNTHESIS OF ISOMERICALLY PURE POLYOL-BASED PHOSPHORAMIDITES

• Main Authors: KUCHELMEISTER, Hannes, BANASIK, Brent, SIMONYIOVA, Sona, TABONE, John C, PFAFFENEDER, Toni, JACOBS, Aaron, JUD, Lukas, DIAZ CORRAL, Julian Andres, NABAVI, Melud, THUER, Wilma
• Format: Patent
• Language: English; French
• Published: 05.10.2023
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; BEER; BIOCHEMISTRY; CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; ENZYMOLOGY; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PERFORMING OPERATIONS; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL; PROCESSES OF PREPARING SUCH COMPOSITIONS; SPIRITS; THEIR RELEVANT APPARATUS; TRANSPORTING; VINEGAR; WINE

The present disclosure relates to a process for the regiochemically and enantiomerically controlled synthesis of phosphoramidite-containing monomers, and to intermediate products of this process. In some embodiments, the phosphoramidite-containing monomers or their precursors are regioisomerically and/or enantiomerically pure and may be polymerized into polymers or copolymers. La présente invention concerne un procédé de synthèse régiochimiquement et énantiomériquement contrôlée de monomères contenant des phosphoramidites, et des produits intermédiaires de ce procédé. Dans certains modes de réalisation, les monomères contenant des phosphoramidites ou leurs précurseurs sont régioisomériquement et/ou énantiomériquement purs et peuvent être polymérisés en polymères ou copolymères.