PROCESS FOR PREPARING ( (1S, 2S) -2- (5-METHYLPYRIDIN-2-YL) CYCLOPROPYL) -METHANOL

Providing an efficient scalable synthesis of compounds of formula 5', such as ((1S, 2S)-2-(5-methylpyridin-2-yl) cyclo-propyl) methanol, which contains a disubstituted cyclopropane with two stereogenic centers and represents a significant challenging synthetic target. L'invention concerne...

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Main Authors LI, Donglin, SHANG, Gao, SNEAD, David R, XIAO, Chengqian, GIBSON, Andrew W, CHUNG, John Y. L, ZHAO, Xiaxia, LIEBERMAN, David R, LÉVESQUE, François, ZHAO, Zhenbing, TAN, Lushi
Format Patent
LanguageEnglish
French
Published 05.10.2023
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:Providing an efficient scalable synthesis of compounds of formula 5', such as ((1S, 2S)-2-(5-methylpyridin-2-yl) cyclo-propyl) methanol, which contains a disubstituted cyclopropane with two stereogenic centers and represents a significant challenging synthetic target. L'invention concerne la fourniture d'une synthèse évolutive efficace de composés de formule 5', tels que le ((1S, 2S)-2-(5-méthylpyridin-2-yl)cyclo-propyl)méthanol, qui contient un cyclopropane disubstitué avec deux centres stéréogènes et représente une cible synthétique de test de provocation significative.
Bibliography:Application Number: WO2022CN84820