PYRIMID-2-YL-PYRAZOLE COMPOUNDS AS IRAK INHIBITORS

Disclosed embodiments concern novel interleukin receptor associated kinases (IRAK) inhibitor compounds and compositions comprising such compounds. The compounds may have a structure according to Formula I (I) Also disclosed are methods of making and using the compounds and compositions. The disclose...

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Bibliographic Details
Main Authors CHEN, Yan, SHAW, Simon, SWEENY, David, MAUNG, Jack, MASUDA, Esteban
Format Patent
LanguageEnglish
French
Published 28.09.2023
Subjects
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Disclosed embodiments concern novel interleukin receptor associated kinases (IRAK) inhibitor compounds and compositions comprising such compounds. The compounds may have a structure according to Formula I (I) Also disclosed are methods of making and using the compounds and compositions. The disclosed compounds and/or compositions may be used to treat or prevent an IRAK-associated disease or condition. Des modes de réalisation de l'invention concernent de nouveaux composés inhibiteurs de kinases associées au récepteur de l'interleukine (IRAK) et des compositions comprenant de tels composés. Les composés peuvent avoir une structure selon la formule I (I). L'invention concerne également des procédés de fabrication et d'utilisation des composés et des compositions. Les composés et/ou les compositions de l'invention peuvent être utilisés pour traiter ou prévenir une maladie ou un état associé à l'IRAK.
Bibliography:Application Number: WO2023US15889