METAGENOMICS FOR MICROORGANISM IDENTIFICATION

Clinical decision support systems and methods for microorganism identification in a sample by determining long-read nucleic acid fragment sequence data (LRS data) originating from a plurality of species in the sample; performing taxonomic classification of the LRS data; determining an abundance leve...

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Main Authors SUPHAVILAI, Chayaporn, KO, Kwan Ki, NAGARAJAN, Niranjan, CHNG, Kern Rei, LIM, Kar Mun
Format Patent
LanguageEnglish
French
Published 09.11.2023
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Abstract Clinical decision support systems and methods for microorganism identification in a sample by determining long-read nucleic acid fragment sequence data (LRS data) originating from a plurality of species in the sample; performing taxonomic classification of the LRS data; determining an abundance levels of a plurality of reference genomes based on taxonomic identifiers of the LRS data; aligning the LRS data with a subset of the reference genomes; performing coverage analysis to determine an identity of one or more microorganism present in the sample based on the coverage analysis. L'invention concerne des systèmes d'aide à la décision clinique et des procédés permettant l'identification de micro-organismes dans un échantillon par détermination de données de séquence de fragments d'acide nucléique à longue lecture (données LRS) provenant d'une pluralité d'espèces dans l'échantillon ; réalisation d'une classification taxonomique des données LRS ; détermination d'un niveau d'abondance d'une pluralité de génomes de référence sur la base d'identifiants taxonomiques des données LRS ; alignement des données LRS avec un sous-ensemble des génomes de référence ; réalisation d'une analyse de couverture pour déterminer une identité d'un ou plusieurs micro-organismes présents dans l'échantillon sur la base de l'analyse de couverture.
AbstractList Clinical decision support systems and methods for microorganism identification in a sample by determining long-read nucleic acid fragment sequence data (LRS data) originating from a plurality of species in the sample; performing taxonomic classification of the LRS data; determining an abundance levels of a plurality of reference genomes based on taxonomic identifiers of the LRS data; aligning the LRS data with a subset of the reference genomes; performing coverage analysis to determine an identity of one or more microorganism present in the sample based on the coverage analysis. L'invention concerne des systèmes d'aide à la décision clinique et des procédés permettant l'identification de micro-organismes dans un échantillon par détermination de données de séquence de fragments d'acide nucléique à longue lecture (données LRS) provenant d'une pluralité d'espèces dans l'échantillon ; réalisation d'une classification taxonomique des données LRS ; détermination d'un niveau d'abondance d'une pluralité de génomes de référence sur la base d'identifiants taxonomiques des données LRS ; alignement des données LRS avec un sous-ensemble des génomes de référence ; réalisation d'une analyse de couverture pour déterminer une identité d'un ou plusieurs micro-organismes présents dans l'échantillon sur la base de l'analyse de couverture.
Author SUPHAVILAI, Chayaporn
NAGARAJAN, Niranjan
CHNG, Kern Rei
KO, Kwan Ki
LIM, Kar Mun
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Snippet Clinical decision support systems and methods for microorganism identification in a sample by determining long-read nucleic acid fragment sequence data (LRS...
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SubjectTerms BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS OR TEST PAPERS THEREFOR
CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES
ENZYMOLOGY
INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS
METALLURGY
MICROBIOLOGY
MUTATION OR GENETIC ENGINEERING
PHYSICS
PROCESSES OF PREPARING SUCH COMPOSITIONS
SPIRITS
TESTING
VINEGAR
WINE
Title METAGENOMICS FOR MICROORGANISM IDENTIFICATION
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